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KMID : 0352519860230030123
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Korea Univercity Medical Journal
1986 Volume.23 No. 3 p.123 ~ p.130
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An immunoenzyme histologic study of distribution of placental alkaline phosphatase in the tissue of female reproductive system
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Abstract
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There are many placental oncofetal antigens or enzymes clinically used in the diagnosis of gynecological cancers. The placental alkaline phosphatase (PAP), one of placental enzyme, is membrane bounded glycoprotein occurring in trophoblasts 12 weeks after gestation.PAP is differentiated from the intestinal or skeletal alkaline phosphatase by its heat stability, electrophoretic migration and other immunologic methods. Recently PAP is reported to be present in the sera of the patients suffering from tumor of the female genital tract, lung, testis or breast. The author had performed immunohistochemical staining using anti PAP sera to determine the presence of PAP in the normal and tumorous gynecologic tissue.
The results are followings.
1. Normal cervical mucosa revealed negative reaction except superficial layer of exocervical squamous cells. And cervical tumors were all negative.
2. Normal and neoplastic lesions of endometrium showed negative reaction. But endometrial
hyperplasia revealed positive reaction in more than 70% of the hyperplastic glands.
3. All normal ovarian tissue components revealed negative reaction to anti PAP but clear cell car-
,inoma, teratocarcinoma and dysgerminoma were tumors showing positive reaction to anti PAP
among ovarian tumors.
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KEYWORD
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